Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice

20 Aug 2010

Abstract excerpt

The transcription factor Fli-1 is implicated in the pathogenesis of both murine and human lupus. Increased levels of Fli-1 mRNA were present in the peripheral blood lymphocytes from lupus patients; furthermore, transgenic overexpression of Fli-1 in normal mice resulted in the development of a lupus-like disease. Lupus nephritis is a major cause of death in both lupus patients as well as in animal models. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20731671
DOI: 10.1111/j.1365-2249.2010.04245.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 micePMID 20731671Read ↗

Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice.Semantic proximity Read ↗

Emerging role of Fli1 in autoimmune diseasesSemantic proximity Read ↗

A Critical Role of the Transcription Factor Fli‐1 in Murine Lupus Development by Regulation of Interleukin‐6 ExpressionSemantic proximity Read ↗

Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.Semantic proximity Read ↗

Single cell RNA sequencing reveals ferritin as a key mediator of autoimmune pre-disposition in a mouse model of systemic lupus erythematosus.Semantic proximity Read ↗

Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus.Semantic proximity Read ↗

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW MiceSemantic proximity Read ↗

The Fli-1 Transcription Factor Regulates the Expression of CCL5/RANTESSemantic proximity Read ↗

Fli1 and Tissue Fibrosis in Various DiseasesSemantic proximity Read ↗

Kallikrein genes are associated with lupus and glomerular basement membrane–specific antibody–induced nephritis in mice and humansSemantic proximity Read ↗

Transcription factor Gfi1 restricts B cell-mediated autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.