Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

PloS one - 15 Nov 2010

Perlot Thomas, Pawlitzky Inka, Manis John P, Zarrin Ali A, Brodeur Peter H, Alt Frederick W

Abstract excerpt

The 5' end of the IgH locus contains a cluster of DNaseI hypersensitive sites, one of which (HS1) was shown to be pro-B cell specific and to contain binding sites for the transcription factors PU.1, E2A, and Pax5. These data as well as the location of the hypersensitive sites at the 5' border of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Flanking Region
Share to Deoxyribonuclease I
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Class Switching

Share to Immunoglobulin Heavy Chains

Share to Lymphocytes

Share to Precursor Cells, B-Lymphoid

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 21085586
DOI: 10.1371/journal.pone.0013992
PMCID: PMC2981565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21085586-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.PMID 21085586Read ↗

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.Semantic proximity Read ↗

Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences.Semantic proximity Read ↗

A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes.Semantic proximity Read ↗

Chromatin Structural Analyses of the Mouse Igκ Gene Locus Reveal New Hypersensitive Sites Specifying a Transcriptional Silencer and EnhancerSemantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.Semantic proximity Read ↗

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Semantic proximity Read ↗

A Multifunctional Element in the Mouse Igκ Locus That Specifies Repertoire and Ig Loci Subnuclear LocationSemantic proximity Read ↗

Physiological role of the 3′IgH CBEs super-anchor in antibody class switchingSemantic proximity Read ↗

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Semantic proximity Read ↗

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.Semantic proximity Read ↗

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.