Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.

doi:10.4049/jimmunol.179.4.2419

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Article

Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2007

Retter Ida, Chevillard Christophe, Scharfe Maren, Conrad Ansgar, Hafner Martin, Im Tschong-Hun, Ludewig Monika, Nordsiek Gabriele, Severitt Simone, Thies Stephanie, Mauhar America, Blöcker Helmut, Müller Werner, Riblet Roy

Abstract excerpt

Although the entire mouse genome has been sequenced, there remain challenges concerning the elucidation of particular complex and polymorphic genomic loci. In the murine Igh locus, different haplotypes exist in different inbred mouse strains. For example, the Igh(b) haplotype sequence of the Mouse Genome Project strain C57BL/6 differs considerably from the Igh(a) haplotype of BALB/c, which has been widely used in...

Topics

Alleles
Animals
Evolution, Molecular
Gene Duplication
Genome
Haplotypes
Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Quantitative Trait Loci

Species Specificity

Source

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Identifiers

PMID: 17675503
DOI: 10.4049/jimmunol.179.4.2419
PMCID: PMC2771210

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