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Article

Physiological role of the 3′IgH CBEs super-anchor in antibody class switching

13 Jan 2021

Abstract excerpt

Significance B lymphocytes change antibody heavy chain (IgH) isotypes by a recombination/deletion process called IgH class switch recombination (CSR). CSR involves introduction of DNA breaks into a donor switch (S) region and also into one of six downstream S regions, with joining of the breaks changing antibody isotype. A chromatin super-anchor, of unknown function, is located just downstream of the IgH locus....

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PMID: 33441485
DOI: 10.1073/pnas.2024392118

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