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Article

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2013

Williams Adam, Lee Gap Ryol, Spilianakis Charalampos G, Hwang Soo Seok, Eisenbarth Stephanie C, Flavell Richard A

Abstract excerpt

The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR. To determine the function of these sites, mutant mice were...

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Identifiers

PMID: 23569250
DOI: 10.1073/pnas.1304720110
PMCID: PMC3637752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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