Article
A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2001
Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T
Abstract excerpt
Chimeric mice were prepared from embryonic stem cells transfected with IgH genes as transgenes and RAG-2-deficient blastocysts for the purpose of identifying the cis-acting elements responsible for the induction of somatic hypermutation. Among the three transgene constructs used, the V(H) promoter, the rearranged V(H)-D-J(H), an intron enhancer/matrix attachment region, and human Cmu were common to all, but the...
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