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Article

Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences.

Immunity - 1 May 2002

Garefalaki Anna, Coles Mark, Hirschberg Sandra, Mavria Georgia, Norton Trisha, Hostert Arnd, Kioussis Dimitris

Abstract excerpt

The developmental and subset-specific expression of the CD8 genes is under the control of a complex array of regulatory elements distributed along the locus and characterized by DNaseI hypersensitivity. Here we describe the phenotype of mice in which hypersensitive sites 1 and 2 (HSS1 and 2) of DNaseI hypersensitive Cluster II (CII), which are located upstream of the CD8 alpha gene, were deleted by targeted...

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Share to CD8 Antigens
Share to Deoxyribonuclease I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Models, Immunological

Share to Organ Culture Techniques

Share to Regulatory Sequences, Nucleic Acid

Share to T-Lymphocyte Subsets

Share to Thymus Gland

Source

Identifiers

PMID: 12049716
DOI: 10.1016/s1074-7613(02)00308-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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