Influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.

doi:10.2133/dmpk.dmpk-10-rg-080

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Article

Influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.

Drug metabolism and pharmacokinetics - 1 Jan 2011

Singh Onkar, Sandanaraj Edwin, Subramanian Koilan, Lee Lai Heng, Chowbay Balram

Abstract excerpt

Warfarin exhibits wide interpatient variability in dosing requirements. Recent studies have shown a novel polymorphism (rs2108622, V433M) in the CYP4F2 gene to be associated with variability in warfarin requirements in Caucasians. The purpose of this study was to evaluate the impact of rs2108622...

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PMID: 21084764
DOI: 10.2133/dmpk.dmpk-10-rg-080

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21084764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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