Article
Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
Pharmacogenomics - 1 Jan 2015
Parra Esteban J, Botton Mariana R, Perini Jamila A, Krithika S, Bourgeois Stephane, Johnson Todd A, Tsunoda Tatsuhiko, Pirmohamed Munir, Wadelius Mia, Limdi Nita A, Cavallari Larisa H, Burmester James K, Rettie Allan E, Klein Teri E, Johnson Julie A, Hutz Mara H, Suarez-Kurtz Guilherme
Abstract excerpt
AIM: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. METHODS: Patients receiving low (≤ 20 mg/week; n = 180) or high stable warfarin doses (≥ 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom(®) Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes...
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