Article
CYP4F2 genetic variant alters required warfarin dose.
Blood - 15 Apr 2008
Caldwell Michael D, Awad Tarif, Johnson Julie A, Gage Brian F, Falkowski Mat, Gardina Paul, Hubbard Jason, Turpaz Yaron, Langaee Taimour Y, Eby Charles, King Cristi R, Brower Amy, Schmelzer John R, Glurich Ingrid, Vidaillet Humberto J, Yale Steven H, Qi Zhang Kai, Berg Richard L, Burmester James K
Abstract excerpt
Warfarin is an effective, commonly prescribed anticoagulant used to treat and prevent thrombotic events. Because of historically high rates of drug-associated adverse events, warfarin remains underprescribed. Further, interindividual variability in therapeutic dose mandates frequent monitoring until target anticoagulation is achieved. Genetic polymorphisms involved in warfarin metabolism and sensitivity have been...
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