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Article

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2009

Atwal Gurinder Singh, Kirchhoff Tomas, Bond Elisabeth E, Montagna Marco, Monagna Marco, Menin Chiara, Bertorelle Roberta, Scaini Maria Chiara, Bartel Frank, Böhnke Anja, Pempe Christina, Gradhand Elise, Hauptmann Steffen, Offit Kenneth, Levine Arnold J, Bond Gareth L

Abstract excerpt

A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants in p53 and MDM2 have shown that single nucleotide polymorphisms (SNPs) can affect p53 signaling, confer cancer risk,...

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Source

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Identifiers

PMID: 19497887
DOI: 10.1073/pnas.0901298106
PMCID: PMC2700939

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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