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Article

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7.

Nucleic acids research - 7 Jul 2017

Perez-Arnaiz Patricia, Bruck Irina, Colbert Max K, Kaplan Daniel L

Abstract excerpt

Mcm10 is an essential eukaryotic factor required for DNA replication. The replication fork helicase is composed of Cdc45, Mcm2-7 and GINS (CMG). DDK is an S-phase-specific kinase required for replication initiation, and the DNA primase-polymerase in eukaryotes is pol α. Mcm10 forms oligomers in vitro, mediated by the coiled-coil domain at the N-terminal region of the protein. We characterized an Mcm10 mutant at...

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PMID: 28510759
DOI: 10.1093/nar/gkx438
PMCID: PMC5499591

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