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Article

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

Disease models & mechanisms - 1 Mar 2011

Bauler Timothy J, Kamiya Nobuhiro, Lapinski Philip E, Langewisch Eric, Mishina Yuji, Wilkinson John E, Feng Gen-Sheng, King Philip D

Abstract excerpt

SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neurological and skeletal abnormalities. To study how SHP-2 regulates tissue homeostasis in normal adults, we used a conditional...

Topics

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Calcification, Physiologic
Cartilage
Hematopoiesis
Macrophage Colony-Stimulating Factor
Osteoclasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Identifiers

PMID: 21068439
DOI: 10.1242/dmm.006130
PMCID: PMC3046097

Genes

PTPN11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.PMID 21068439Read ↗

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