Article
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.
Molecular and cellular biology - 1 Oct 1998
Qu C K, Yu W M, Azzarelli B, Cooper S, Broxmeyer H E, Feng G S
Abstract excerpt
Shp-2 is a cytoplasmic tyrosine phosphatase that contains two Src homology 2 (SH2) domains at the N terminus. Biochemical data suggests that Shp-2 acts downstream of a variety of receptor and cytoplasmic tyrosine kinases. A targeted deletion mutation in the N-terminal SH2 (SH2-N) domain results i...
Topics
- Animals
- Cell Line
- Hematopoiesis
- Intracellular Signaling Peptides and Proteins
- Liver
- Mice
- Mice, Knockout
- Mutation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Yolk Sac