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Article

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.

Molecular and cellular biology - 1 Oct 1998

Qu C K, Yu W M, Azzarelli B, Cooper S, Broxmeyer H E, Feng G S

Abstract excerpt

Shp-2 is a cytoplasmic tyrosine phosphatase that contains two Src homology 2 (SH2) domains at the N terminus. Biochemical data suggests that Shp-2 acts downstream of a variety of receptor and cytoplasmic tyrosine kinases. A targeted deletion mutation in the N-terminal SH2 (SH2-N) domain results in embryonic lethality of homozygous mutant mice at midgestation. In vitro embryonic stem (ES) cell differentiation...

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Identifiers

PMID: 9742124
DOI: 10.1128/MCB.18.10.6075
PMCID: PMC109193

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Source receipt: pubmed, retrieved 7 Sept 2026.

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