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Article

Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.

Rheumatology (Oxford, England) - 1 Jul 2015

Liao Hsiu-Jung, Chyuan I-Tsu, Wu Chien-Sheng, Lin Shu-Wha, Chen Kun-Hung, Tsai Hwei-Fang, Hsu Ping-Ning

Abstract excerpt

OBJECTIVE: Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is involved in macrophage activation, neutrophil motility and osteoclast differentiation. However, the role of PSTPIP2 in inflammation and autoinflammatory diseases is still not clear. In this study, we generated PSTPIP2 knockout (Pstpip2(-/-)) mice to investigate its phenotype and role in autoinflammatory diseases. METHODS: We...

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Source

Identifiers

PMID: 25602062
DOI: 10.1093/rheumatology/keu481

Genes

PSTPIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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