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Article

Distinct and overlapping functions of ptpn11 genes in Zebrafish development.

PloS one - 1 Jan 2014

Bonetti Monica, Rodriguez-Martinez Virginia, Paardekooper Overman Jeroen, Overvoorde John, van Eekelen Mark, Jopling Chris, Hertog Jeroen den

Abstract excerpt

The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in PTPN11 are associated with Noonan and LEOPARD syndrome. Human patients with these autosomal dominant disorders display various symptoms, including short stature, craniofacial defects and heart abnormalities. We have used the zebrafish as a model to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24736444
DOI: 10.1371/journal.pone.0094884
PMCID: PMC3988099

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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