Article
The role of the protein tyrosine phosphatase SHP2 in ossification.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2022
Zhang Yuan, Lu Wei, Zhao Qing, Chen Jindong, Wang Tiancong, Ji Jun
Abstract excerpt
SHP2, encoded by the PTPN11 gene, participates in multiple cell functions including cell proliferation, movement, and differentiation. PTPN11 loss-of-function and gain-of-function mutations are both associated with diseases, such as Noonan syndrome, whose manifestations include bone defects, suggesting a crucial role for SHP2 in the skeleton. However, the exact mechanisms by which SHP2 regulates bone development...
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