Article
The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.
Seminars in cell & developmental biology - 1 Jan 2015
Lauriol Jessica, Jaffré Fabrice, Kontaridis Maria I
Abstract excerpt
Congenital heart disease is the most common human developmental disorder, affecting ∼1:100 newborns, and is the primary cause of birth-defect related deaths worldwide. As a major regulator of receptor tyrosine kinase (RTK), cytokine and G-protein coupled receptor signaling, the non-receptor protein tyrosine phosphatase SHP2 plays a critical role in normal cardiac development and function. Indeed, SHP2...
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