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Article

SHP2 sails from physiology to pathology.

European journal of medical genetics - 1 Oct 2015

Tajan Mylène, de Rocca Serra Audrey, Valet Philippe, Edouard Thomas, Yart Armelle

Abstract excerpt

Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been identified as the causal factor of several developmental diseases (Noonan syndrome (NS), Noonan syndrome with multiple lentigines (NS-ML), and metachondromatosis), and malignancies (juvenile myelomonocytic leukemia). SHP2 plays essential...

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Source

Identifiers

PMID: 26341048
DOI: 10.1016/j.ejmg.2015.08.005

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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