Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[The Biological Function of SHP2 in Human Disease].

Molekuliarnaia biologiia - 1 Jan 2000

Li S M

Abstract excerpt

Tyrosyl phosphorylation participates in various pathological and physiological processes, which are regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). The Src homology-2 domain containing phosphatase SHP2 (encoded by PTPN11) is an important phosphatase, which was found to be implicated in the regulation of genetic disease, development, metabolic, neurological, muscle, skeletal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PTPN11 gene
Share to LEOPARD Syndrome
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Noonan Syndrome

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Signal Transduction

Source

Identifiers

PMID: 27028808
DOI: 10.7868/S0026898416010110

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[The Biological Function of SHP2 in Human Disease].PMID 27028808Read ↗

Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis.Semantic proximity Read ↗

Functions of Shp2 in cancer.Semantic proximity Read ↗

SHP2 sails from physiology to pathology.Semantic proximity Read ↗

Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.Semantic proximity Read ↗

The tyrosine phosphatase Shp2 (PTPN11) in cancer.Semantic proximity Read ↗

The role of the protein tyrosine phosphatase SHP2 in ossification.Semantic proximity Read ↗

Targeting SHP2 phosphatase in hematological malignancies.Semantic proximity Read ↗

The role of Shp2 (PTPN11) in cancer.Semantic proximity Read ↗

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.Semantic proximity Read ↗

The Landscape of Protein Tyrosine Phosphatase (Shp2) and CancerSemantic proximity Read ↗

The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Semantic proximity Read ↗

Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.