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Article

SHP-2 and myeloid malignancies.

Current opinion in hematology - 1 Jan 2004

Tartaglia Marco, Niemeyer Charlotte M, Shannon Kevin M, Loh Mignon L

Abstract excerpt

PURPOSE OF REVIEW: This review focuses on the non-receptor Src-homology 2 domain-containing protein tyrosine phosphatase SHP-2 and its role in signal transduction, hematopoiesis, and leukemogenesis. Specifically, we discuss the role of inherited and somatic mutations that result in SHP-2 gain-of-function in human disease, including myeloid malignancies. RECENT FINDINGS: Up-regulation of RAS signaling is a major...

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Share to Hematopoiesis
Share to Intracellular Signaling Peptides and Proteins
Share to Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Noonan Syndrome

Share to Protein Structure, Tertiary

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Share to Signal Transduction

Source

Identifiers

PMID: 14676626
DOI: 10.1097/00062752-200401000-00007

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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