Article
Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.
Immunology - 1 Feb 1990
O'Callaghan D, Maskell D, Tite J, Dougan G
Abstract excerpt
Two near isogenic strains of Salmonella typhimurium HWSH, stably mutated in either the aroA gene affecting the biosynthesis of aromatic compounds, or the purA gene affecting the biosynthesis of purines, were administered intravenously as live attenuated vaccines to BALB/c mice. HWSH aroA-immunized mice were well protected against intravenous (i.v.) challenge with wild-type virulent HWSH for at least 10 weeks,...
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