Article
Salmonella typhi and S typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors.
Vaccine - 17 Jan 2003
Khan Shahid A, Stratford Richard, Wu Tao, Mckelvie Nicola, Bellaby Trevor, Hindle Zoe, Sinha Katharine A, Eltze Shayne, Mastroeni Piero, Pickard Derek, Dougan Gordon, Chatfield Steven N, Brennan Frank R
Abstract excerpt
The S. typhimurium strain (TML deltaaroC deltassaV) WT05, harbouring defined deletions in genes involved in both the aromatic biosynthesis pathway (aroC) and the Salmonella Pathogenicity Island-2 (SPI-2) (ssaV) was shown to be significantly attenuated in C57 BL/6 interferon gamma knockout mice following oral inoculation. Similarly, the S. typhi strain (Ty2 deltaaroC deltassaV) ZH9 harbouring the aroC and ssaV...
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