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Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nu/nu) BALB/c mice.

Infection and immunity - 1 Apr 1997

Sinha K, Mastroeni P, Harrison J, de Hormaeche R D, Hormaeche C E

Abstract excerpt

Athymic (nu/nu) BALB/c mice and their euthymic (nu/+) littermates were inoculated intravenously with live attenuated vaccine strains of Salmonella typhimurium. All strains caused progressive infections in the athymic mice but not in their euthymic littermates. Athymic mice given strain SL3261, an aroA derivative of SL1344, in doses between log 4.7 and 5.7 CFU were all severely ill and were killed by weeks 4 to 5....

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Identifiers

PMID: 9119506
DOI: 10.1128/iai.65.4.1566-1569.1997
PMCID: PMC175172

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Source receipt: pubmed, retrieved 7 Sept 2026.

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