Article
Moderate immunodeficiency does not increase susceptibility to Salmonella typhimurium aroA live vaccines in mice.
Infection and immunity - 1 Jul 1990
Izhar M, DeSilva L, Joysey H S, Hormaeche C E
Abstract excerpt
Salmonellae carrying appropriate mutations in genes of the aromatic biosynthesis pathway are effective as live vaccines in animals, and they are candidate typhoid vaccines for human use. They are also very effective as carriers of recombinant antigens from other pathogens to the immune system, el...
Topics
- Animals
- Bacterial Vaccines
- Disease Susceptibility
- Female
- Immunologic Deficiency Syndromes
- Kinetics
- Lethal Dose 50
- Liver
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Salmonella Infections, Animal
- Salmonella typhimurium
- Spleen
- Vaccines, Attenuated
- Virulence