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Article

Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants.

Infection and immunity - 1 Oct 2004

Stritzker Jochen, Janda Jozef, Schoen Christoph, Taupp Marcus, Pilgrim Sabine, Gentschev Ivaylo, Schreier Peter, Geginat Gernot, Goebel Werner

Abstract excerpt

Mutants of Listeria monocytogenes with deletions in genes of the common branch of the biosynthesis pathway leading to aromatic compounds were constructed as possible virulence-attenuated carrier strains for protein antigens or vaccine DNA. aroA, aroB, and in particular aroE mutants showed strongly reduced growth rates in epithelial cells and even in rich culture media. The metabolism of the aro mutants under...

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Identifiers

PMID: 15385459
DOI: 10.1128/IAI.72.10.5622-5629.2004
PMCID: PMC517589

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Source receipt: pubmed, retrieved 7 Sept 2026.

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