Article
Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice.
Infection and immunity - 1 Dec 1993
Turner S J, Carbone F R, Strugnell R A
Abstract excerpt
Recombinant Salmonella typhimurium aroA aroD mutants which expressed ovalbumin were constructed. The two expression constructs used were based on either pUC18 or pBR322. The pBR322-based construct was more stable in vitro and in vivo than the pUC-based construct. Salmonellae containing the stable...
Topics
- Animals
- Antibodies, Bacterial
- Antigens, Bacterial
- Cloning, Molecular
- Female
- Gene Expression
- Histocompatibility Antigens Class I
- Mice
- Mutation
- Ovalbumin
- Recombinant Proteins
- Salmonella Infections, Animal
- Salmonella typhimurium
- T-Lymphocytes, Cytotoxic