Article
Immunization against anthrax with aromatic compound-dependent (Aro-) mutants of Bacillus anthracis and with recombinant strains of Bacillus subtilis that produce anthrax protective antigen.
Infection and immunity - 1 Feb 1990
Ivins B E, Welkos S L, Knudson G B, Little S F
Abstract excerpt
The safety and efficacy of five prototype, live anthrax vaccines were studied in Hartley guinea pigs and CBA/J and A/J mice. Two of the strains, Bacillus anthracis FD111 and FD112, are Aro- mutants derived by Tn916 mutagenesis of B. anthracis UM23-1. Bacillus subtilis PA1 and PA2 contain a recombinant plasmid, pPA101 or pPA102, respectively, that carries the gene from B. anthracis encoding synthesis of protective...
Topics
- Animals
- Anthrax
- Antigens, Bacterial
- Bacillus anthracis
- Bacillus subtilis
- Bacterial Vaccines
- Female
- Guinea Pigs
- Immunization
- Male
- Mice