Mice vaccinated with a non-virulent, aromatic-dependent mutant of Salmonella choleraesuis die from challenge with its virulent parent but survive challenge with Salmonella typhimurium.

Abstract excerpt

BALB/c mice given a live vaccine of an aroA mutant of Salmonella choleraesuis by intraperitoneal (i.p.) injection were not protected against i.p. challenge with its virulent parental strain but were protected against i.p. challenge with either of two virulent strains of Salmonella typhimurium (O [1], 4, [5], 12). Vaccination with a live vaccine of S. typhimurium aroA protected against challenge with S....

Topics

• Animals
• Bacterial Vaccines
• Injections, Intraperitoneal
• Lethal Dose 50
• Mice
• Mice, Inbred BALB C
• Mutation
• Salmonella
• Salmonella typhimurium
• Species Specificity
• Specific Pathogen-Free Organisms