Article
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.
Microbial pathogenesis - 1 Feb 1992
Chatfield S N, Strahan K, Pickard D, Charles I G, Hormaeche C E, Dougan G
Abstract excerpt
Derivatives of the mouse-virulent Salmonella typhimurium strain SL1344 were constructed harbouring defined mutations in htrA, aroA or htrA aroA combined. When administered orally or intravenously to BALB/c mice, all the mutants were found to be highly attenuated. All mutants were able to confer s...
Topics
- Animals
- Bacterial Vaccines
- Blotting, Southern
- Cloning, Molecular
- Disease Models, Animal
- Heat-Shock Proteins
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mutation
- Restriction Mapping
- Salmonella Infections, Animal
- Salmonella typhimurium
- Vaccines, Attenuated
- Virulence