Article
Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice.
Journal of microbiology (Seoul, Korea) - 1 Aug 2010
Piao Hong Hua, Tam Vo Thi Minh, Na Hee Sam, Kim Hyun Ju, Ryu Phil Youl, Kim Soo Young, Rhee Joon Haeng, Choy Hyon E, Kim Suhng Wook, Hong Yeongjin
Abstract excerpt
Attenuated bacteria have long been developed as vaccine candidates but can have some disadvantages, such as the potential for damage to immune organs due to insufficient clearance. To minimize these disadvantages, we generated Salmonella enterica serovar Typhimurium mutants SHJ2104 (asd::cm) and HTSaYA (wzy::km, asd::cm). The wzy gene codes for the O-antigen polymerase, which is involved in lipopolysaccharide...
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