Article
Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon.
Molecular microbiology - 1 Oct 1996
Coynault C, Robbe-Saule V, Norel F
Abstract excerpt
The alternative sigma factor RpoS (sigma S) is required for Salmonella virulence in mice. We report the immunizing capacity of Salmonella typhimurium rpoS and rpoS aroA mutants to protect susceptible BALB/c mice against subsequent oral challenge with virulent S. typhimurium. When administered ora...
Topics
- 3-Phosphoshikimate 1-Carboxyvinyltransferase
- Administration, Oral
- Alkyl and Aryl Transferases
- Animals
- Bacterial Proteins
- Bacterial Vaccines
- Disease Models, Animal
- Female
- Mice
- Mice, Inbred BALB C
- Mutation
- Regulon
- Salmonella Infections, Animal
- Salmonella typhimurium
- Sigma Factor
- Spleen
- Transferases
- Vaccination