Article
In silico QTL mapping of basal liver iron levels in inbred mouse strains.
Physiological genomics - 11 Feb 2011
McLachlan Stela, Lee Seung-Min, Steele Teresa M, Hawthorne Paula L, Zapala Matthew A, Eskin Eleazar, Schork Nicholas J, Anderson Gregory J, Vulpe Chris D
Abstract excerpt
Both iron deficiency and iron excess are detrimental in many organisms, and previous studies in both mice and humans suggest that genetic variation may influence iron status in mammals. However, these genetic factors are not well defined. To address this issue, we measured basal liver iron levels in 18 inbred strains of mice of both sexes on a defined iron diet and found ∼4-fold variation in liver iron in males...
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