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Article

Fine-mapping and genetic analysis of the loci affecting hepatic iron overload in mice.

PloS one - 1 Jan 2013

Guo Xin, Zhang Zhuzhen, Zhang Fan, Tao Yunlong, An Peng, Wu Qian, Wang Chia-Yu, Knutson Mitchell D, Wang Fudi

Abstract excerpt

The liver, as the major organ for iron storage and production of hepcidin, plays pivotal roles in maintaining mammalian iron homeostasis. A previous study showed that Quantitative Trait Loci (QTLs) on chromosome 7 (Chr7) and 16 (Chr16) may control hepatic non-heme iron overload in an F2 intercross derived from C57BL/6J (B6) and SWR/J (SWR) mice. In this study, we aimed to validate the existence of these loci and...

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PMID: 23675470
DOI: 10.1371/journal.pone.0063280
PMCID: PMC3651197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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