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Article

Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains.

Aging cell - 1 Oct 2010

Leduc Magalie S, Hageman Rachael S, Meng Qingying, Verdugo Ricardo A, Tsaih Shirng-Wern, Churchill Gary A, Paigen Beverly, Yuan Rong

Abstract excerpt

The IGF-1 signaling pathway plays an important role in regulating longevity. To identify the genetic loci and genes that regulate plasma IGF-1 levels, we intercrossed MRL/MpJ and SM/J, inbred mouse strains that differ in IGF-1 levels. Quantitative trait loci (QTL) analysis of IGF-1 levels of these F2 mice detected four QTL on chromosomes (Chrs) 9 (48 Mb), 10 (86 Mb), 15 (18 Mb), and 17 (85 Mb). Haplotype...

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Identifiers

PMID: 20735370
DOI: 10.1111/j.1474-9726.2010.00612.x
PMCID: PMC3025299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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