Article
Multiple polymorphic loci determine basal hepatic and splenic iron status in mice.
Hepatology (Baltimore, Md.) - 1 Jul 2006
Grant Gemma R, Robinson Susan W, Edwards Richard E, Clothier Bruce, Davies Reginald, Judah David J, Broman Karl W, Smith Andrew G
Abstract excerpt
Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in levels of non-heme iron, with C57BL/6J and SWR showing low and high levels, respectively. The genetic basis for this variability was examined using quantitative...
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