Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains.

Abstract excerpt

Excessive absorption of dietary iron results in pathologic hepatic iron accumulation in the genetic disorder hemochromatosis. Genetic factors have also been suggested to play a role in African iron overload that is induced by the intake of iron-rich fermented beer. We have used inbred strains of mice to investigate previously unrecognized genetic factors controlling iron metabolism. Among different strains of...

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