Article
Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains.
Blood cells, molecules & diseases - 1 Jan 2000
Ajioka Richard S, LeBoeuf Renee C, Gillespie Ryan R, Amon Lynn M, Kushner James P
Abstract excerpt
The highly variable clinical phenotype observed in patients homozygous for the C282Y mutation of the hereditary hemochromatosis gene (HFE) is likely due to the influence of non-HFE modifier genes. The primary functional abnormality causing iron overload in hemochromatosis is hyper-absorption of dietary iron. We found that iron absorption in inbred mice varies in a strain-specific manner, as does the pattern of...
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