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Article

Multigenic control of hepatic iron loading in a murine model of hemochromatosis.

Gastroenterology - 1 May 2004

Bensaid Mounia, Fruchon Séverine, Mazères Christine, Bahram Seiamak, Roth Marie-Paule, Coppin Hélène

Abstract excerpt

BACKGROUND & AIMS: Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-predisposing genotype in the general population become iron loaded. Genetic modifiers have been...

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Source

Identifiers

PMID: 15131800
DOI: 10.1053/j.gastro.2004.01.021

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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