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Article

Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.

PLoS genetics - 28 Oct 2010

Lefevre Gaelle M, Patel Sanjeevkumar R, Kim Doyeob, Tessarollo Lino, Dressler Gregory R

Abstract excerpt

Methylation of specific lysine residues in core histone proteins is essential for embryonic development and can impart active and inactive epigenetic marks on chromatin domains. The ubiquitous nuclear protein PTIP is encoded by the Paxip1 gene and is an essential component of a histone H3 lysine 4 (H3K4) methyltransferase complex conserved in metazoans. In order to determine if PTIP and its associated complexes...

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Identifiers

PMID: 21060806
DOI: 10.1371/journal.pgen.1001142
PMCID: PMC2965754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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