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Article

Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2024

Wang Gang, Wu Hangdi, Zhai Xiuwen, Zhang Li, Zhang Changming, Cheng Chen, Xu Xiaodong, Gao Erzhi, Xiong Xushen, Zhang Jin, Liu Zhihong

Abstract excerpt

Wilms tumor-1(WT1) is a crucial transcription factor that regulates podocyte development. However, the epigenomic mechanism underlying the function of WT1 during podocyte development has yet to be fully elucidated. Here, single-cell chromatin accessibility and gene expression maps of foetal kidneys and kidney organoids are generated. Functional implications of WT1-targeted genes, which are crucial for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38810140
DOI: 10.1002/advs.202308556
PMCID: PMC11304319

Genes

WT1
MAGI2
MYH9
NPHS1
BMPER
PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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