Article
Mice with a Pax2 missense variant display impaired glomerular repair.
American journal of physiology. Renal physiology - 1 May 2024
Cunanan Joanna, Rajyam Sarada Sriya, Sharif Bedra, Udwan Khalil, Rana Akanchaya, De Gregorio Vanessa, Ricardo Samantha, Elia Andrew, Brooks Brian, Weins Astrid, Pollak Martin, John Rohan, Barua Moumita
Abstract excerpt
PAX2 regulates kidney development, and its expression persists in parietal epithelial cells (PECs), potentially serving as a podocyte reserve. We hypothesized that mice with a Pax2 pathogenic missense variant (Pax2A220G/+) have impaired PEC-mediated podocyte regeneration. Embryonic wild-type mouse kidneys showed overlapping expression of PAX2/Wilms' tumor-1 (WT-1) until PEC and podocyte differentiation,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.