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Article

KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria.

The Journal of clinical investigation - 1 Jun 2014

Hayashi Kaori, Sasamura Hiroyuki, Nakamura Mari, Azegami Tatsuhiko, Oguchi Hideyo, Sakamaki Yusuke, Itoh Hiroshi

Abstract excerpt

The transcription factor Kruppel-like factor 4 (KLF4) has the ability, along with other factors, to reprogram somatic cells into induced pluripotent stem (iPS) cells. Here, we determined that KLF4 is expressed in kidney glomerular podocytes and is decreased in both animal models and humans exhibiting a proteinuric. Transient restoration of KLF4 expression in podocytes of diseased glomeruli in vivo, either by gene...

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Source

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Identifiers

PMID: 24812666
DOI: 10.1172/JCI69557
PMCID: PMC4089466

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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