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Article

A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus.

The Journal of biological chemistry - 2 Apr 2004

Srichai Manakan B, Konieczkowski Martha, Padiyar Aparna, Konieczkowski David J, Mukherjee Amitava, Hayden Patrick S, Kamat Sweta, El-Meanawy M Ashraf, Khan Shenaz, Mundel Peter, Lee Sean Bong, Bruggeman Leslie A, Schelling Jeffrey R, Sedor John R

Abstract excerpt

Glomerular podocyte differentiation state is critical for filtration barrier function and is regulated by WT1, a zinc finger transcription factor. A yeast two-hybrid assay identified a novel, WT1-interacting protein (WTIP) that maps to human chromosome 19q13.1, a region with genes linked to familial focal segmental glomerulosclerosis. The domain structure of WTIP is similar to the zyxin subfamily of cytosolic LIM...

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Identifiers

PMID: 14736876
DOI: 10.1074/jbc.M314155200

Genes

WTIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus.PMID 14736876Read ↗

Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP).Semantic proximity Read ↗

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Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read ↗

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.Semantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

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Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.Semantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.Semantic proximity Read ↗

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