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Article

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.

Nature structural & molecular biology - 1 Dec 2010

McGee Jean S, Phillips Jane A, Chan Angela, Sabourin Michelle, Paeschke Katrin, Zakian Virginia A

Abstract excerpt

Telomerase in Saccharomyces cerevisiae binds and preferentially elongates short telomeres, and this process requires the checkpoint kinase Tel1. Here we show that the Mre11 complex bound preferentially to short telomeres, which could explain the preferential binding of Tel1 to these ends. Compared to wild-type length telomeres, short telomeres generated by incomplete replication had low levels of the telomerase...

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Identifiers

PMID: 21057524
DOI: 10.1038/nsmb.1947
PMCID: PMC3058685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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