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Article

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.

Molecular and cellular biology - 1 May 2012

Martina Marina, Clerici Michela, Baldo Veronica, Bonetti Diego, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

Generation of G-strand overhangs at Saccharomyces cerevisiae yeast telomeres depends primarily on the MRX (Mre11-Rad50-Xrs2) complex, which is also necessary to maintain telomere length by recruiting the Tel1 kinase. MRX physically interacts with Rif2, which inhibits both resection and elongation of telomeres. We provide evidence that regulation of telomere processing and elongation relies on a balance between...

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Source

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Identifiers

PMID: 22354991
DOI: 10.1128/MCB.06547-11
PMCID: PMC3347235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.PMID 22354991Read ↗

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