Article
Telomerase Repairs Collapsed Replication Forks at Telomeres.
Cell reports - 10 Mar 2020
Matmati Samah, Lambert Sarah, Géli Vincent, Coulon Stéphane
Abstract excerpt
Telomeres are difficult-to-replicate sites whereby replication itself may threaten telomere integrity. We investigate, in fission yeast, telomere replication dynamics in telomerase-negative cells to unmask problems associated with telomere replication. Two-dimensional gel analysis reveals that replication of telomeres is severely impaired and correlates with an accumulation of replication intermediates that...
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