Article
p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions.
Hepatology (Baltimore, Md.) - 1 Apr 1998
Kalkuhl A, Troppmair J, Buchmann A, Stinchcombe S, Buenemann C L, Rapp U R, Kaestner K, Schwarz M
Abstract excerpt
Mouse liver tumors frequently harbor activating ras gene mutations. Downstream effector molecules of p21Ras include Raf-1 kinase which mediates external signals via kinase signaling pathways to nuclear transcription factors including c-Fos and c-Jun. Mouse liver tumors with differing ras-mutational status were analyzed for alterations in Ras/Raf-1 signal transduction. Tumors were characterized with respect to the...
Topics
- Animals
- Cell Division
- Genes, fos
- Genes, jun
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mutation