Article
Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1993
Soman N R, Wogan G N
Abstract excerpt
Sequence alterations in the exon 1 region of the rat c-Ki-ras gene were studied in DNA isolated from aflatoxin B1 (AFB1)-induced rat liver carcinomas and precursor lesions appearing 56 weeks after administration of the carcinogen. To detect the mutations with high sensitivity, DNA samples were an...
Topics
- Adenoma
- Aflatoxin B1
- Animals
- Base Sequence
- Electrophoresis, Agar Gel
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Liver Neoplasms
- Liver Neoplasms, Experimental
- Molecular Sequence Data
- Mutation
- Nucleic Acid Denaturation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Precancerous Conditions
- Proto-Oncogene Proteins p21(ras)
- Rats