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Article

Prevalence of MPL W515L/K mutations in Taiwanese patients with Philadelphia-negative chronic myeloproliferative neoplasms.

Journal of the Chinese Medical Association : JCMA - 1 Oct 2010

Lieu Chien-Hui, Shen Yu-Jie, Lai Wei-Chih, Tsai Wen-Hui, Hsu Hui-Chi

Abstract excerpt

BACKGROUND: The discovery of Janus kinase 2 (JAK2)-V617F has provided important insight into the pathogenesis of Philadelphia-negative chronic myeloproliferative neoplasms (Ph-negative MPNs); however, the etiology of JAK2(V617F)-negative Ph-negative MPN remains unidentified. MPL(W515L) and MPL(W515K) (MPL(W515L/K)) are 2 gain-of-function mutations, which have been found in some Ph-negative MPN patients from...

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Source

Identifiers

PMID: 21051030
DOI: 10.1016/S1726-4901(10)70115-5

Genes

MPL
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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